CRISPR SCREEN OF VENETOCLAX RESPONSE-ASSOCIATED GENES IDENTIFIES TRANSCRIPTION FACTOR ZNF740 AS A KEY FUNCTIONAL REGULATOR

CRISPR screen of venetoclax response-associated genes identifies transcription factor ZNF740 as a key functional regulator

Abstract BCL-2 inhibitors such as venetoclax offer therapeutic promise in acute myeloid leukemia (AML) and other cancers, but drug resistance poses a significant challenge.It is crucial to understand the mechanisms that regulate venetoclax response.While correlative studies have identified numerous genes HDMI Splitters linked to venetoclax sensitiv

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Detecting disease-associated genotype patterns

Abstract Background In addition to single-locus (main) effects of disease variants, there is a growing consensus that gene-gene and gene-environment interactions may play important roles in disease etiology.However, for the very large numbers of genetic markers currently in use, it has proven difficult to develop suitable and efficient approaches f

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Parallel Dense Video Caption Generation with Multi-Modal Features

The task of dense video captioning is to generate detailed natural-language descriptions for an original video, which requires deep analysis and mining of semantic captions to identify events in the video.Existing methods typically follow a localisation-then-captioning sequence within given frame sequences, resulting in caption generation that is h

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