CRISPR screen of venetoclax response-associated genes identifies transcription factor ZNF740 as a key functional regulator
Abstract BCL-2 inhibitors such as venetoclax offer therapeutic promise in acute myeloid leukemia (AML) and other cancers, but drug resistance poses a significant challenge.It is crucial to understand the mechanisms that regulate venetoclax response.While correlative studies have identified numerous genes HDMI Splitters linked to venetoclax sensitiv